The UCD Cancer Data Lab, led by Dr. Colm J. Ryan, use large-scale data analysis to understand how genetic variation in cancer alters molecular interaction networks and to identify ways to target these alterations therapeutically.
Recent News
Swathi’s paper on the influence of antibody quality on mRNA-protein correlations
Congrats to Swathi on the publication of her work to understand the influence of antibody quality on the mRNA-protein correlations observed in tumour cohorts.
Congratulations to Dr. Thomas Lefeivre
Congratulations to Dr. Thomas Lefeivre, who successfully defended his thesis ‘Investigation of the functional interplay between signalling pathways and epigenetic factors in acute leukaemia’ on April 18th.
Cosmin’s paper on using Gene Regulatory Networks to predict gene essentiality in cancer
Gene regulatory networks (GRNs) are widely used to understand how driver mutations in tumours alter transcriptional networks and to identify new therapeutic targets. Here, we use genome-wide CRISPR screen data to systematically evaluate the ability of GRNs to predict sensitivity to genetic perturbation in cancer.
End of year symposium - ICBG2022
Just approaching the end of the year, we had the opportunity to present our work at #ICGB2022.
We are hiring!
We are currently looking for computational postdoctoral fellows! More details here Photo above is from a lab hike during COVID times. In Dublin we cannot promise constant sunshine, but we can promise the benefits of living in a capital city coupled with close proximity to the sea and some lovely scenery.
The return of in person conferences!
After more than two years with conference travel halted due to COVID-19, lab members have finally had the opportunity to attend in person conferences.
Swathi’s paper on the relationship between mRNA and protein abundances
Everyone knows that there is an imperfect correlation between mRNA and protein abundances. In Swathi’s recent paper we analysed how much measurement (ir)reproducibility contributes to this.
Lab move to the Conway Institute!
After some happy and productive years at Systems Biology Ireland we have moved to the adjacent Conway Institute of Biomolecular and Biomedical Research
Thomas presents at Spetses Summer School
Congratulations to Thomas Lefeivre, who is a member of both the Bond Group and the Ryan group for giving a talk titled ‘The loss of PRC2 function diversely impacts signalling pathway activity in acute leukaemia’ at the Spetses Summer School 2022.
Congratulations to Dr. Barbara De Kegel!
Congratulations to Dr. Barbara De Kegel, who passed her viva with flying colours last week.
Swathi wins Best Student Talk at IMSS 2022
Congratulations to Swathi Ramachandra Upadhya for winning the prize for best student talk at the Irish Mass Spectrometry Society Conference 2022.
Our group are affiliated with the UCD School of Computer Science and based in the Conway Institute of Biomolecular and Biomedical Research. Various lab members are also affiliated with Systems Biology Ireland and the SFI Centre for Research Training in Genomics Data Science.