2

Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer
Although defects in the RB1 tumour suppressor are one of the more common driver alterations found in triple-negative breast cancer …
Cite DOI Paper
E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit …
Cite DOI Paper
A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events
Protein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors …
Cite DOI Paper Source Code Dataset
CancerGD: a resource for identifying and interpreting genetic dependencies in cancer
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for …
Cite DOI Paper Source Code
Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast
This protocol describes computational analysis of genetic interaction screens, ranging from data capture (plate imaging) to downstream …
Cite DOI Paper
High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe
Epistasis mapping, in which the phenotype that emerges from combining pairs of mutations is measured quantitatively, is a powerful tool …
Cite DOI Paper
The histone variant H2A. Z promotes splicing of weak introns
Multiple lines of evidence implicate chromatin in the regulation of premessenger RNA (pre-mRNA) splicing. However, the influence of …
Cite DOI Paper
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
Identifying genetic biomarkers of synthetic lethal drug sensitivity effects provides one approach to the development of targeted cancer …
Cite DOI Paper
Large-scale profiling of kinase dependencies in cancer cell lines
One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell …
Cite DOI Paper
Genetic Interaction Mapping Reveals a Role for the SWI/SNF Nucleosome Remodeler in Spliceosome Activation in Fission Yeast
Although numerous regulatory connections between pre-mRNA splicing and chromatin have been demonstrated, the precise mechanisms by …
Cite DOI Paper