Colm J. Ryan

Latest

• Cross-species identification of PIP5K1-, splicing-and ubiquitin-related pathways as potential targets for RB1-deficient cells
• Systems biology: old news or new stimulus for biochemistry
• Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer
• ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
• Large-scale profiling of kinase dependencies in cancer cell lines
• Genetic Interaction Mapping Reveals a Role for the SWI/SNF Nucleosome Remodeler in Spliceosome Activation in Fission Yeast
• Evolutionarily conserved genetic interactions with budding and fission yeast &#119872&#119906&#119905&#119878 identify orthologous relationships in mismatch repair-deficient cancer cells
• Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function
• Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae
• Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation