UCD Cancer Data Lab
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DAISY: picking synthetic lethals from cancer genomes
A better understanding of genetic interactions in cancer might help identify new therapeutic approaches that exploit the concept of …
Colm J. Ryan
,
Christopher J Lord
,
Alan Ashworth
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DOI
Paper
Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function
Condensin is a central regulator of mitotic genome structure with mutants showing poorly condensed chromosomes and profound segregation …
Hyun-Soo Kim
,
Rituparna Mukhopadhyay
,
Scott B Rothbart
,
Andrea C Silva
,
Vincent Vanoosthuyse
,
Ernest Radovani
,
Thomas Kislinger
,
Assen Roguev
,
Colm J. Ryan
,
Jiewei Xu
,
others
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DOI
Paper
Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae
Current approaches for identifying synergistic targets use cell culture models to see if the combined effect of clinically available …
Joseph I Kliegman
,
Dorothea Fiedler
,
Colm J. Ryan
,
Yi-Fan Xu
,
Xiao-yang Su
,
David Thomas
,
Max C Caccese
,
Ada Cheng
,
Michael Shales
,
Joshua D Rabinowitz
,
others
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DOI
Paper
High-resolution network biology: connecting sequence with function
Proteins are not monolithic entities; rather, they can contain multiple domains that mediate distinct interactions, and their …
Colm J. Ryan
,
Peter Cimermančič
,
Zachary A Szpiech
,
Andrej Sali
,
Ryan D Hernandez
,
Nevan J Krogan
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DOI
Paper
Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation
Genetic interactions reveal the functional relationships between pairs of genes. In this study, we describe a method for the systematic …
James E Haber
,
Hannes Braberg
,
Qiuqin Wu
,
Richard Alexander
,
Julian Haase
,
Colm J. Ryan
,
Zach Lipkin-Moore
,
Kathleen E Franks-Skiba
,
Tasha Johnson
,
Michael Shales
,
others
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DOI
Paper
All or nothing: protein complexes flip essentiality between distantly related eukaryotes
In the budding yeast
Saccharomyces cerevisiae
, the subunits of any given protein complex are either mostly essential or mostly …
Colm J. Ryan
,
Nevan J Krogan
,
Pádraig Cunningham
,
Gerard Cagney
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DOI
Paper
The yeast SR-like protein Npl3 links chromatin modification to mRNA processing
Eukaryotic gene expression involves tight coordination between transcription and pre–mRNA splicing; however, factors responsible for …
Erica A Moehle
,
Colm J. Ryan
,
Nevan J Krogan
,
Tracy L Kress
,
Christine Guthrie
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DOI
Paper
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting …
Colm J. Ryan
,
Assen Roguev
,
Kristin Patrick
,
Jiewei Xu
,
Harlizawati Jahari
,
Zongtian Tong
,
Pedro Beltrao
,
Michael Shales
,
Hong Qu
,
Sean R Collins
,
others
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DOI
Paper
Comparative interaction networks: bridging genotype to phenotype
Over the past decade, biomedical research has witnessed an exponential increase in the throughput of the characterization of biological …
Pedro Beltrao
,
Colm J. Ryan
,
Nevan J Krogan
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DOI
Paper
Key Functional Regions in the Histone Variant H2A.Z C-Terminal Docking Domain
The incorporation of histone variants into nucleosomes represents one way of altering the chromatin structure to accommodate diverse …
Alice Y Wang
,
Maria J Aristizabal
,
Colm J. Ryan
,
Nevan J Krogan
,
Michael S Kobor
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