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Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression
Epistasis (synergistic interaction) among SNPs governing gene expression is likely to arise within transcriptional networks. However, …
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Evolutionarily conserved genetic interactions with budding and fission yeast &#119872&#119906&#119905&#119878 identify orthologous relationships in mismatch repair-deficient cancer cells
The evolutionarily conserved DNA mismatch repair (MMR) system corrects base-substitution and insertion-deletion mutations generated …
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DAISY: picking synthetic lethals from cancer genomes
A better understanding of genetic interactions in cancer might help identify new therapeutic approaches that exploit the concept of …
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Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function
Condensin is a central regulator of mitotic genome structure with mutants showing poorly condensed chromosomes and profound segregation …
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Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae
Current approaches for identifying synergistic targets use cell culture models to see if the combined effect of clinically available …
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High-resolution network biology: connecting sequence with function
Proteins are not monolithic entities; rather, they can contain multiple domains that mediate distinct interactions, and their …
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Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation
Genetic interactions reveal the functional relationships between pairs of genes. In this study, we describe a method for the systematic …
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All or nothing: protein complexes flip essentiality between distantly related eukaryotes
In the budding yeast Saccharomyces cerevisiae, the subunits of any given protein complex are either mostly essential or mostly …
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The yeast SR-like protein Npl3 links chromatin modification to mRNA processing
Eukaryotic gene expression involves tight coordination between transcription and pre–mRNA splicing; however, factors responsible for …
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Hierarchical Modularity and the Evolution of Genetic Interactomes across Species
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting …
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