UCD Cancer Data Lab
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Accurate prediction of kinase-substrate networks using knowledge graphs
Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular …
Vı́t Nováček
,
Gavin McGauran
,
David Matallanas
,
Adrián Vallejo Blanco
,
Piero Conca
,
Emir Muñoz
,
Luca Costabello
,
Kamalesh Kanakaraj
,
Zeeshan Nawaz
,
Brian Walsh
,
others
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DOI
Paper
Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions
Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using …
Christopher J Lord
,
Niall Quinn
,
Colm J. Ryan
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DOI
Paper
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASᴳ¹³ᴰ
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these …
Susan A Kennedy
,
Mohamed-Ali Jarboui
,
Sriganesh Srihari
,
Cinzia Raso
,
Kenneth Bryan
,
Layal Dernayka
,
Theodosia Charitou
,
Manuel Bernal-Llinares
,
Carlos Herrera-Montavez
,
Aleksandar Krstic
,
others
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DOI
Paper
Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival
Small cell lung cancer (SCLC) accounts for 15% of lung cancers and is almost always linked to inactivating
RB1
and
TP53
mutations. SCLC …
Matthew G Oser
,
Raquel Fonseca
,
Abhishek A Chakraborty
,
Rachel Brough
,
Alexander Spektor
,
Rebecca B Jennings
,
Abdallah Flaifel
,
Jesse S Novak
,
Aditi Gulati
,
Elizabeth Buss
,
others
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DOI
Paper
Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
What makes a gene essential for cellular survival? In model organisms, such as budding yeast, systematic gene deletion studies have …
Barbara De Kegel
,
Colm J. Ryan
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DOI
Paper
Synthetic Lethality and Cancer – Penetrance as the Major Barrier
Synthetic lethality has long been proposed as an approach for targeting genetic defects in tumours. Despite a decade of screening …
Colm J. Ryan
,
Ilirjana Bajrami
,
Christopher J Lord
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DOI
Paper
Systems biology: old news or new stimulus for biochemistry
In this issue of Essays in Biochemistry, biochemistry meets systems biology—a blind date that may hold all the promises, pitfalls and …
Walter Kolch
,
Dirk Fey
,
Colm J. Ryan
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DOI
Paper
Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness
Osteosarcoma (OS) is an aggressive sarcoma, where novel treatment approaches are required. Genomic studies suggest that a subset of OS, …
Harriett Holme
,
Aditi Gulati
,
Rachel Brough
,
Emmy DG Fleuren
,
Ilirjana Bajrami
,
James Campbell
,
Irene Y Chong
,
Sara Costa-Cabral
,
Richard Elliott
,
Tim Fenton
,
others
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DOI
Paper
Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer
Although defects in the
RB1
tumour suppressor are one of the more common driver alterations found in triple-negative breast cancer …
Rachel Brough
,
Aditi Gulati
,
Syed Haider
,
Rahul Kumar
,
James Campbell
,
Erik Knudsen
,
Stephen J Pettitt
,
Colm J. Ryan
,
Christopher J Lord
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DOI
Paper
E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit …
Ilirjana Bajrami
,
Rebecca Marlow
,
Marieke van de Ven
,
Rachel Brough
,
Helen N Pemberton
,
Jessica Frankum
,
Feifei Song
,
Rumana Rafiq
,
Asha Konde
,
Dragomir B Krastev
,
others
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DOI
Paper
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