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Genetic interactions under the microscope
Traditional genetic interaction screens profile phenotypes at aggregate level, missing interactions that may influence the distribution …
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Antibody reliability influences observed mRNA–protein correlations in tumour samples
Reverse phase protein arrays (RPPA) have been used to quantify the abundance of hundreds of proteins across thousands of tumour samples …
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Targeting synthetic lethal paralogs in cancer
Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition of another gene, can be exploited for …
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Experimental reproducibility limits the correlation between mRNA and protein abundances in tumour proteomic profiles
Large-scale studies of human proteomes have revealed only a moderate correlation between mRNA and protein abundances. It is unclear to …
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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Pairs of paralogs may share common functionality and, hence, display synthetic lethal interactions. As the majority of human genes have …
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Proteomic signatures of radioresistance: Alteration of inflammation, angiogenesis and metabolism-related factors in radioresistant oesophageal adenocarcinoma
The clinical management of locally advanced oesophageal adenocarcinoma (OAC) involves neoadjuvant chemoradiotherapy (CRT), but as …
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Cross-species identification of PIP5K1-, splicing-and ubiquitin-related pathways as potential targets for RB1-deficient cells
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, …
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Accurate prediction of kinase-substrate networks using knowledge graphs
Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular …
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Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions
Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using …
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Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS&#7475&#185&#179&#7472
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these …
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