synthetic lethality

Identifying genetic dependencies in cancer by analyzing siRNA screens in tumor cell line panels
Loss-of-function screening using RNA interference or CRISPR approaches can be used to identify genes that specific tumor cell lines …
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CancerGD: a resource for identifying and interpreting genetic dependencies in cancer
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for …
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Large-scale profiling of kinase dependencies in cancer cell lines
One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell …
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