synthetic lethality

Exploiting Cancer Synthetic Lethality in Cancer---Lessons Learnt from PARP Inhibitors
PARP inhibitors now have proven utility in the treatment of homologous recombination (HR) defective cancers. These drugs, and the …
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Targeting synthetic lethal paralogs in cancer
Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition of another gene, can be exploited for …
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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Pairs of paralogs may share common functionality and, hence, display synthetic lethal interactions. As the majority of human genes have …
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Cross-species identification of PIP5K1-, splicing-and ubiquitin-related pathways as potential targets for RB1-deficient cells
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, …
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Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions
Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using …
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Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival
Small cell lung cancer (SCLC) accounts for 15% of lung cancers and is almost always linked to inactivating RB1 and TP53 mutations. SCLC …
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Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
What makes a gene essential for cellular survival? In model organisms, such as budding yeast, systematic gene deletion studies have …
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Synthetic Lethality and Cancer – Penetrance as the Major Barrier
Synthetic lethality has long been proposed as an approach for targeting genetic defects in tumours. Despite a decade of screening …
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E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit …
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Identifying genetic dependencies in cancer by analyzing siRNA screens in tumor cell line panels
Loss-of-function screening using RNA interference or CRISPR approaches can be used to identify genes that specific tumor cell lines …
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