cancer

Antibody reliability influences observed mRNA–protein correlations in tumour samples
Reverse phase protein arrays (RPPA) have been used to quantify the abundance of hundreds of proteins across thousands of tumour samples …
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Paralog dispensability shapes homozygous deletion patterns in tumor genomes
Tumor genomes abound with mutations, including homozygous gene deletions, suggesting that tumors are robust to genetic perturbation. In …
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Cross-species identification of PIP5K1-, splicing-and ubiquitin-related pathways as potential targets for RB1-deficient cells
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, …
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Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions
Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using …
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Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival
Small cell lung cancer (SCLC) accounts for 15% of lung cancers and is almost always linked to inactivating RB1 and TP53 mutations. SCLC …
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Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
What makes a gene essential for cellular survival? In model organisms, such as budding yeast, systematic gene deletion studies have …
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Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness
Osteosarcoma (OS) is an aggressive sarcoma, where novel treatment approaches are required. Genomic studies suggest that a subset of OS, …
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E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit …
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Identifying genetic dependencies in cancer by analyzing siRNA screens in tumor cell line panels
Loss-of-function screening using RNA interference or CRISPR approaches can be used to identify genes that specific tumor cell lines …
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A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events
Protein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors …
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