cancer

Complex synthetic lethality in cancer
The concept of synthetic lethality has been widely applied to identify therapeutic targets in cancer, with varying degrees of success. …
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Exploiting Cancer Synthetic Lethality in Cancer---Lessons Learnt from PARP Inhibitors
PARP inhibitors now have proven utility in the treatment of homologous recombination (HR) defective cancers. These drugs, and the …
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Antibody reliability influences observed mRNA–protein correlations in tumour samples
Reverse phase protein arrays (RPPA) have been used to quantify the abundance of hundreds of proteins across thousands of tumour samples …
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Cross-species identification of PIP5K1-, splicing-and ubiquitin-related pathways as potential targets for RB1-deficient cells
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, …
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Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions
Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using …
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Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival
Small cell lung cancer (SCLC) accounts for 15% of lung cancers and is almost always linked to inactivating RB1 and TP53 mutations. SCLC …
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Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
What makes a gene essential for cellular survival? In model organisms, such as budding yeast, systematic gene deletion studies have …
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Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness
Osteosarcoma (OS) is an aggressive sarcoma, where novel treatment approaches are required. Genomic studies suggest that a subset of OS, …
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E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit …
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Identifying genetic dependencies in cancer by analyzing siRNA screens in tumor cell line panels
Loss-of-function screening using RNA interference or CRISPR approaches can be used to identify genes that specific tumor cell lines …
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