UCD Cancer Data Lab
UCD Cancer Data Lab
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Comparative interaction networks: bridging genotype to phenotype
Over the past decade, biomedical research has witnessed an exponential increase in the throughput of the characterization of biological …
Pedro Beltrao
,
Colm J. Ryan
,
Nevan J Krogan
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DOI
Paper
Key Functional Regions in the Histone Variant H2A.Z C-Terminal Docking Domain
The incorporation of histone variants into nucleosomes represents one way of altering the chromatin structure to accommodate diverse …
Alice Y Wang
,
Maria J Aristizabal
,
Colm J. Ryan
,
Nevan J Krogan
,
Michael S Kobor
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DOI
Paper
Improved functional overview of protein complexes using inferred epistatic relationships
Epistatic Miniarray Profiling (E-MAP) quantifies the net effect on growth rate of disrupting pairs of genes, often producing phenotypes …
Colm J. Ryan
,
Derek Greene
,
Aude Guénolé
,
Haico van Attikum
,
Nevan J Krogan
,
Pádraig Cunningham
,
Gerard Cagney
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DOI
Paper
Missing value imputation for epistatic MAPs
Epistatic miniarray profiling (E-MAPs) is a high-throughput approach capable of quantifying aggravating or alleviating genetic …
Colm J. Ryan
,
Derek Greene
,
Gerard Cagney
,
Pádraig Cunningham
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DOI
Paper
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