2

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options. To comprehensively map monogenic and …
Cite DOI URL
Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer
AbstractProteins operate within dense interconnected networks, with interactions necessary both for stabilising proteins and enabling …
Cite DOI URL
Complex synthetic lethality in cancer
The concept of synthetic lethality has been widely applied to identify therapeutic targets in cancer, with varying degrees of success. …
Cite DOI Paper
Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity
Gene regulatory networks (GRNs) are often deregulated in tumor cells, resulting in altered transcriptional programs that facilitate …
Cite DOI Paper Source Code
Paralog dispensability shapes homozygous deletion patterns in tumor genomes
Genomic instability is a hallmark of cancer, resulting in tumor genomes having large numbers of genetic aberrations, including …
Cite DOI Paper Source Code
Genetic interactions under the microscope
Traditional genetic interaction screens profile phenotypes at aggregate level, missing interactions that may influence the distribution …
Cite DOI Paper
Antibody reliability influences observed mRNA–protein correlations in tumour samples
Reverse phase protein arrays (RPPA) have been used to quantify the abundance of hundreds of proteins across thousands of tumour samples …
Cite DOI Paper Source Code
Targeting synthetic lethal paralogs in cancer
Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition of another gene, can be exploited for …
Cite DOI Paper
Experimental reproducibility limits the correlation between mRNA and protein abundances in tumour proteomic profiles
Large-scale studies of human proteomes have revealed only a moderate correlation between mRNA and protein abundances. It is unclear to …
Cite Video DOI Paper Source Code
Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Pairs of paralogs may share common functionality and, hence, display synthetic lethal interactions. As the majority of human genes have …
Cite Video DOI Paper Predictions and Supplementary Data Source Code