Gene regulatory networks (GRNs) are widely used to understand how driver mutations in tumours alter transcriptional networks and to identify new therapeutic targets. Here, we use genome-wide CRISPR screen data to systematically evaluate the ability of GRNs to predict sensitivity to genetic perturbation in cancer.
Just approaching the end of the year, we had the opportunity to present our work at #ICGB2022.
After more than two years with conference travel halted due to COVID-19, lab members have finally had the opportunity to attend in person conferences.
Everyone knows that there is an imperfect correlation between mRNA and protein abundances. In Swathi’s recent paper we analysed how much measurement (ir)reproducibility contributes to this.
After some happy and productive years at Systems Biology Ireland we have moved to the adjacent Conway Institute of Biomolecular and Biomedical Research
Congratulations to Thomas Lefeivre, who is a member of both the Bond Group and the Ryan group for giving a talk titled ‘The loss of PRC2 function diversely impacts signalling pathway activity in acute leukaemia’ at the Spetses Summer School 2022.
Congratulations to Dr. Barbara De Kegel, who passed her viva with flying colours last week.
Congratulations to Swathi Ramachandra Upadhya for winning the prize for best student talk at the Irish Mass Spectrometry Society Conference 2022.