Cosmin’s paper on using Gene Regulatory Networks to predict gene essentiality in cancer

Gene regulatory networks (GRNs) are widely used to understand how driver mutations in tumours alter transcriptional networks and to identify new therapeutic targets. Here, we use genome-wide CRISPR screen data to systematically evaluate the ability of GRNs to predict sensitivity to genetic perturbation in cancer.

End of year symposium - ICBG2022

Just approaching the end of the year, we had the opportunity to present our work at #ICGB2022.

We are hiring!
We are currently looking for computational postdoctoral fellows! More details here Photo above is from a lab hike during COVID times. In Dublin we cannot promise constant sunshine, but we can promise the benefits of living in a capital city coupled with close proximity to the sea and some lovely scenery.
The return of in person conferences!

After more than two years with conference travel halted due to COVID-19, lab members have finally had the opportunity to attend in person conferences.

Swathi’s paper on the relationship between mRNA and protein abundances

Everyone knows that there is an imperfect correlation between mRNA and protein abundances. In Swathi’s recent paper we analysed how much measurement (ir)reproducibility contributes to this.

Thomas presents at Spetses Summer School

Congratulations to Thomas Lefeivre, who is a member of both the Bond Group and the Ryan group for giving a talk titled ‘The loss of PRC2 function diversely impacts signalling pathway activity in acute leukaemia’ at the Spetses Summer School 2022.

Congratulations to Dr. Barbara De Kegel!

Congratulations to Dr. Barbara De Kegel, who passed her viva with flying colours last week.