UCD Cancer Data Lab
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proteogenomics
Antibody reliability influences observed mRNA–protein correlations in tumour samples
Reverse phase protein arrays (RPPA) have been used to quantify the abundance of hundreds of proteins across thousands of tumour samples …
Swathi Ramachandra Upadhya
,
Colm J. Ryan
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Experimental reproducibility limits the correlation between mRNA and protein abundances in tumour proteomic profiles
Large-scale studies of human proteomes have revealed only a moderate correlation between mRNA and protein abundances. It is unclear to …
Swathi Ramachandra Upadhya
,
Colm J. Ryan
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A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events
Protein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors …
Colm J. Ryan
,
Susan Kennedy
,
Ilirjana Bajrami
,
David Matallanas
,
Christopher J Lord
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