paralogs

Paralog dispensability shapes homozygous deletion patterns in tumor genomes
Genomic instability is a hallmark of cancer, resulting in tumor genomes having large numbers of genetic aberrations, including …
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Targeting synthetic lethal paralogs in cancer
Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition of another gene, can be exploited for …
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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Pairs of paralogs may share common functionality and, hence, display synthetic lethal interactions. As the majority of human genes have …
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