genetic interactions

Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Pairs of paralogs may share common functionality and, hence, display synthetic lethal interactions. As the majority of human genes have …
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CancerGD: a resource for identifying and interpreting genetic dependencies in cancer
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for …
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All or nothing: protein complexes flip essentiality between distantly related eukaryotes
In the budding yeast Saccharomyces cerevisiae, the subunits of any given protein complex are either mostly essential or mostly …
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