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Exploiting Cancer Synthetic Lethality in Cancer---Lessons Learnt from PARP Inhibitors
PARP inhibitors now have proven utility in the treatment of homologous recombination (HR) defective cancers. These drugs, and the …
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Identifying genetic dependencies in cancer by analyzing siRNA screens in tumor cell line panels
Loss-of-function screening using RNA interference or CRISPR approaches can be used to identify genes that specific tumor cell lines …
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Imputing and predicting quantitative genetic interactions in epistatic MAPs
Mapping epistatic (or genetic) interactions has emerged as an important network biology approach for establishing functional …
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