3

Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity

Gene regulatory networks (GRNs) are often deregulated in tumor cells, resulting in altered transcriptional programs that facilitate …

Cosmin Tudose, Jonathan Bond, Colm J. Ryan

Paralog dispensability shapes homozygous deletion patterns in tumor genomes

Tumor genomes abound with mutations, including homozygous gene deletions, suggesting that tumors are robust to genetic perturbation. In …

Barbara De Kegel, Colm J. Ryan