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Benchmarking Genetic Interaction Scoring Methods for Identifying Synthetic Lethality from Combinatorial CRISPR Screens
Synthetic lethality (SL) is an extreme form of negative genetic interaction, where simultaneous disruption of two non-essential genes …
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Evaluating Sequence and Structural Similarity Metrics for Predicting Shared Paralog Functions
Gene duplication is the primary source of new genes, resulting in most genes having identifiable paralogs. Over evolutionary time …
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Paralog protein compensation preserves protein-protein interaction networks following gene loss in cancer
Proteins operate within dense interconnected networks, where interactions are necessary both for stabilising proteins and for enabling …
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