Barbara's paper on homozygous deletions of paralogs in cancer
Barbara’s paralog deletion paper
Congrats to Dr. Barbara De Kegel on the publication of her work to understand how the dispensability of paralogs shapes homozygous deletion patterns in tumors.
Tumors tolerate astonishing numbers of genetic alterations, including the homozygous deletion of entire protein coding genes. In this work we explore one potential explanation – paralogs! The paper is out in its final form in Molecular Systems Biology here.
You can read the original tweetorial about the preprint below:
the latest work from @dekegelb. Tumors tolerate astonishing numbers of genetic alterations, including homozygous deletion of entire protein coding genes. This suggests significant genetic robustness https://t.co/TQWYcrlp0e 1/11
— Colm Ryan (@colmr) June 27, 2022
