Rachel Brough

Latest

• Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival
• Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness
• Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer
• E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
• ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
• Large-scale profiling of kinase dependencies in cancer cell lines