others

Latest

• Accurate prediction of kinase-substrate networks using knowledge graphs
• Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS&#7475&#185&#179&#7472
• Cells lacking the RB1 tumor suppressor gene are hyperdependent on Aurora B kinase for survival
• Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness
• E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
• ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
• Large-scale profiling of kinase dependencies in cancer cell lines
• Evolutionarily conserved genetic interactions with budding and fission yeast &#119872&#119906&#119905&#119878 identify orthologous relationships in mismatch repair-deficient cancer cells
• Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function
• Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae
• Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation
• Hierarchical Modularity and the Evolution of Genetic Interactomes across Species